We have focussed on constructing bacterial-membrane mimicking systems including Gram-positive membranes, Gram-negative inner and outer-membranes for studying the transport of small hydrophilic molecules across membranes, membrane proteins and understanding pore-forming properties of antimicrobial peptides.  We employ Giant unilamellar vesicles (GUVs) as our membrane model system. Apart from working on membrane transport, we have also investigated the role of native lipids in membrane bending and shape transformation employing the engineered cell membrane mimicking models.